2-Deoxy-d-glucose reduces epileptiform activity by presynaptic mechanisms
نویسندگان
چکیده
منابع مشابه
Antiangiogenic Activity of 2-Deoxy-D-Glucose
BACKGROUND During tumor angiogenesis, endothelial cells (ECs) are engaged in a number of energy consuming biological processes, such as proliferation, migration, and capillary formation. Since glucose uptake and metabolism are increased to meet this energy need, the effects of the glycolytic inhibitor 2-deoxy-D-glucose (2-DG) on in vitro and in vivo angiogenesis were investigated. METHODOLOGY...
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PURPOSE 2-Deoxy-D-glucose (2-DG), a glucose analog that accumulates in cells and interferes with carbohydrate metabolism by inhibiting glycolytic enzymes, has anticonvulsant actions. Recognizing that severe glucose deprivation can induce seizures, we sought to determine whether acute treatment with 2-DG can promote seizure susceptibility by assessing its effects on seizure threshold. For compar...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2019
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00723.2018